The Dr. Johannes and Hertha Tuba Foundation Grants

The Dr. Johannes and Hertha Tuba Foundation Grants

Innovative projects from basic research and applied research in the field of old age and aging are rewarded annually at the Medical University of Innsbruck with prizes from the Dr. Johannes and Hertha Tuba Foundation. In 2021, funding for snorkel research will go to microbiologist Michael Ausserlechner, the award for outstanding scientific publication to neurologist Christian Böhme.

On behalf of Dr. Johannes and Hertha Tuba-Foundation, the Medical University of Innsbruck invites applications for projects in the fields of gerontology and geriatrics, the results of which make a significant contribution to improving the situation of the elderly. This is intended to directly promote the research activities of scientists at the highest level.

Promising skin model from 3D printer

Skin aging is at the center of Michael Ausserlechner’s project, supported by Tuba research funds. “With 3D bioprinting, we develop a structured 3D skin model from human cells in so-called ‘fluidic chips’, which contains structures similar to blood vessels and spontaneously forms fine capillaries”, explains the microbiologist , describing the core of the project, which aims to induce aging processes and test strategies to either delay skin aging or specifically eliminate aged skin cells. In addition, the innovative skin model makes it possible to avoid animal testing in medical-pharmaceutical research and offers a wide range of applications in the fields of contact toxicity and cosmetics, infection research and allergies and cancer research. Ausserlechner and his team use cell-loaded protein gels to build the skin model, which the 3D bioprinter stacks in layers. “The skin pattern then grows independently until it has three layers and consists of blood vessels, connective tissue and, at the top, epithelium with the stratum corneum, which forms the barrier to environment. We use this model of human skin to look closely at aging processes,” says Ausserlechner.

To no one

Michael Ausserlechner, who was born in East Tyrol, studied microbiology at the University of Innsbruck, where he also did his doctorate, then joined the Medical University of Innsbruck as a postdoc, where he obtained his habilitation after spending time abroad and setting up a group physiopathology research center. In addition to the development of new mechanical tools for cellular research, the head of the molecular biology research laboratory mainly studies the molecular mechanisms of tumor development.

Michael Ausserlechner explains his project in the video:

Risk factor attitude and lifestyle at time of stroke

As blood vessels age, the risk of stroke increases. “However, a large proportion of strokes, which are the second leading cause of death worldwide and a leading cause of disability in adults, could be prevented if existing risk factors are addressed and a healthy lifestyle is maintained,” says neurologist Christian Böhme, who has studied the relevance of risk and lifestyle factors at the time of stroke and has now received the Tuba Award for Outstanding Scientific Publication. Those of the newspaper Neurology published work (The dimension of preventable stroke in a large representative cohort of patients. C. Böhme et al., Neurology 2019 December 3
https://doi.org/10.1212/WNL.0000000000008573) provides a quantitative basis for developing preventive action strategies to avoid stroke and maintain vascular health. 1,730 patients with ischemic stroke and transient ischemic attack (TIA) were included in the study. Overall, almost 80% of patients had at least one untreated or insufficiently treated risk factor at the time of the stroke; after additional consideration for an unhealthy lifestyle, this value increased to 95%. “Appropriate adjustment of the five most common risk factors could have prevented approximately one in two stroke events,” Böhme comments on the study results, which confirm a large gap between evidence-based stroke prevention and the implementation of prevention strategies in the real world. .

To no one :

Born in Innsbruck in 1987, Christian Böhme first studied physiotherapy at the Innsbruck University of Applied Sciences before graduating with honors in human medicine from the Medical University of Innsbruck. Strokes resulting from atherosclerotic changes in the vessels are the focus of research for the neurologist, who also earned his doctorate in clinical neuroscience with distinction.

Christian Böhme describes his research results in the video:

Doctor Research funding from Johannes and Hertha Tuba

Hofrat Prim.Dr. Johannes Tuba was for many years primary and director of the public hospital in Hochzirl, which he co-founded. On behalf of Dr. Johannes and Hertha Tuba-Foundation, the Medical University of Innsbruck awards prizes. Grants are awarded for innovative projects in the field of basic medical research and application-oriented research and development related to issues of old age and aging, the results of which contribute significantly to the improvement of the situation of the elderly. The aim is the direct promotion of science and the research activities of scientists at the highest level.

(03/31/2022, text: D. Heidegger, photos and videos: MUI/Bullock)

Left:

3D bioprinting laboratory
https://www.i-med.ac.at/bioprinting/

University neurology clinic
https://www.i-med.ac.at/neurology/

Doctor Research funding from Johannes and Hertha Tuba
https://www.i-med.ac.at/forschung/foerderungen/Dr.-Johannes-und-Hertha-Tuba-Forschungsfoerderung.html

Doctor Price Johannes and Hertha Tuba
https://www.i-med.ac.at/forschung/foerderungen/Dr.-Johannes-Tuba-Prize.html

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